Featherstone’s James Mendeika and Liam Kent are set to miss the rest of the campaign.
They are both likely to require knee surgery.
Hooker George Flanagan has already been ruled out for the remainder of the season after he sustained a broken leg in Sunday’s win against Barrow.
Rovers skipper Tim Spears is targeting the home game against Sheffield on August 31 to make his comeback from a torn bicep and Jamie Cording could be back for the play-offs.
Andy Kain and Matty Dale are both available for tomorrow’s match at Leigh after being rested last weekend.
Ben Blackmore returned against Barrow after missing four games with an ankle injury and Sam Smeaton made his first senior appearance for two years last Sunday following knee surgery.
Featherstone coach Andy Hay said: “George Flanagan has been playing well for us. He’s passionate and full of enthusiasm and just loves playing. It’s bad when anyone gets an injury like that but it’s probably worse when it’s someone like he is.
“We’ve got Andy Ellis, Andy Kain and Jack Bussey and young Luke Teasdale has been playing really well in the under 20s so we’ve got options at hooker.
“Even though we’ve got players out with long-term injuries, we are still okay squad wise.
“Ben Blackmore got through the game against Barrow and was fine with it on Monday. It was more of a case of getting him out there and seeing how he was and pushing Will Sharp and Jason Crookes a little bit and keeping them on their toes.
“I thought Sam Smeaton had a good game. He didn’t do much wrong and he’s very solidly defensively. He’s good around the team and talks really well.
“He showed some nice touches and it’s good to get that one out of the way. He got through the full 80 minutes and he’s had no problems afterwards. It’s really good to see him back and it gives us another option.
“Andy Kain and Matty Dale were rested last weekend. We had a short turaround with Friday’s match at Leigh and Andy has played in almost every game and done really well for us.
“We thought we could do without him against Barrow and we did. I also wanted to see Jamie Rooney and Gareth Moore together in the halves and give them more game time. Matty Dale has toughed it out the last few weeks so we thought we could rest him ahead of Friday’s game.”