Lock Lane visit Wath Brow Hornets in the Ladbrokes Challenge Cup second round.
Other ties include Siddal v Featherstone Lions or Queens, Normanton Knights v Shaw Cross or York Acorn and Oulton Raiders v Valley Cougars.
Ties are to be played over the weekend of February 14 and 15.
In the first round, Lock Lane hammered Sharlston Rovers 64-0, Oulton Raiders trounced Scarborough Pirates 62-6 and Normanton beat Myton Warriors 34-16.
Featherstone Lions host Queens in a re-arranged first round tie at the Mill Pond Stadium, Wakefield Road, this Saturday (1.30pm) after last weekend’s match was postponed.
The other second round ties are Hunslet Warriors v West Hull, Hull Dockers v Walney Central, Kells v Notts Outlaws or Blackbrook, Elland v Egremont Rangers, Widnes West Bank v Rochdale Mayfield, Skirlaugh v Royal Navy.