Featherstone Lions visit Elland and Oulton Raiders host Normanton Knights in the third round of the Ladbrokes Challenge Cup.
League One newcomers Coventry have been drawn away to Oldham.
At least three non-league teams are guaranteed places in the fourth round, when the 12 Kingstone Press Championship clubs enter the tournament, after the draw - made by rugby league legends Alex Murphy and Malcolm Reilly at Huddersfield University - paired six of the remaining amateur clubs together.
Matches will be played on the weekennd of March 7 and 8.
The third round ties are:
North Wales v Widnes West Bank
Elland v Featherstone Lions
Wath Brow Hornets v Newcastle Thunder
Hemel Stags v Oxford
Oulton Raiders v Normanton
Leigh Miners v West Hull
Oldham v Coventry
Kells v Rochdale
London Skolars v Swinton
Barrow v Keighley
South Wales Scorpions v York
University of Gloucestershire v Skirlaugh.