The M62 motorway is blocked after a collision between a van and a car.
It happened on the westbound carriageway between junction 34 at Selby and junction 33 at Ferrybidge services.
Firefighters from Pontefract, Castleford and Selby were called to the incident just before 3pm.
A woman who was travelling in the car has been taken to hospital by the Air Ambulance.
Drivers have been warned to expect delays until further notice.